English Premier League predictions, fixtures and results: 25 – 27 September 2021

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A heavy duty English Premier League weekend sees the big hitters go head-to-head at the top of the standings.

Reigning EPL champions Manchester City kick off the fixtures in the Saturday lunchtime match when they go to early leaders Chelsea.

Pep Guardiola’s men are three points off the pace in fifth thanks to an opening day defeat, while the Blues have four wins and a draw from their opening five to head the standings on goal difference.

The capital city is the centre of attention on Sunday, too, as Arsenal and Tottenham contest the north London derby at the Emirates Stadium.

Contrasting form is the order of the day as Mikel Arteta’s Gunners have picked up from a horrible start with back-to-back EPL victories, while Spurs’ perfect record has bitten the dust with two defeats on the bounce.

Manchester United are also in the mix at the top thanks to a Cristiano Ronaldo-inspired start to the campaign.

They have home advantage on Saturday lunchtime as Aston Villa visit Old Trafford.

Fellow north west high-flyers Liverpool must wait until the evening kick off, with Jurgen Klopp’s men playing away to promoted Brentford.

The Reds’ Merseyside neighbours Everton saw their unbeaten start to life under Rafa Benitez go pop last time out, but the Toffees have the perfect opportunity for redemption as pointless Norwich make the trip to Goodison Park.

West Ham face a test of their top half credentials away to a Leeds side yet to win this term, with the Hammers seeking a first victory in four attempts.

Leicester could also use some impetus to spark another top six tilt under Brendan Rodgers, with grinders Burnley to visitors to the King Power Stadium.

A Vicarage Road clash between Watford and Newcastle completes the Saturday programme, with the pressure piled high on Toon boss Steve Bruce.

Another pair of early strugglers, Southampton and Wolves, meet at St Mary’s Stadium in the early Sunday game.

It’s a much happier tale along the south coast at Brighton, though, as the Seagulls fly into the weekend in fourth place off the back of four wins from five.

Graham Potter’s side are in derby action on Monday night, as they head up to Selhurst Park to face Patrick Vieira’s Crystal Palace.

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English Premier League predictions for 25 – 27 September

Prediction methodology explainedThe expected win percentage is based off publicly available odds. For example, if a team’s odds are 2.30, the expected chance of winning is 43%. If the odds are 1.62 the expected chance of winning is 62% and so on. These are accurate at the time of writing but are subject to change. Where there is no value listed, the odds were not available at the time of writing.

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